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Maturational arrest from CD4+8+ to CD4+8− thymocytes is caused by the bone marrow-derived cells in LEC mutant rats

✍ Scribed by Tohru Sakai; Takashi Agui; Kozo Matsumoto

Book ID: 107908465
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 398 KB
Volume: 38
Category: Article
ISSN: 0165-2478
DOI: 10.1016/0165-2478(93)90180-a

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## Abstract LEC rats bear a congenital deficiency in CD4^+^CD8^−^ thymocytes and peripheral CD4^+^ T cells, and consequently a deficiency in T~h~ cell functions. Ontogeny of T cell maturation in normal and LEC mutant rats was, therefore, investigated. Prenatal development of thymocytes in normal ra