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Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets

✍ Scribed by Pia Vihinen; Veli-Matti Kähäri

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
250 KB
Volume
99
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Degradation of extracellular matrix is crucial for malignant tumour growth, invasion, metastasis and angiogenesis. Matrix metalloproteinases (MMPs) are a family of zinc‐dependent neutral endopeptidases collectively capable of degrading essentially all matrix components. Elevated levels of distinct MMPs can be detected in tumour tissue or serum of patients with advanced cancer and their role as prognostic indicators in cancer is studied. In addition, therapeutic intervention of tumour growth and invasion based on inhibition of MMP activity is under intensive investigation and several MMP inhibitors are in clinical trials in cancer. In this review, we discuss the current view on the feasibility of MMPs as prognostic markers and as targets for therapeutic intervention in cancer. © 2002 Wiley‐Liss, Inc.

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