## Abstract Degradation of extracellular matrix is crucial for malignant tumour growth, invasion, metastasis and angiogenesis. Matrix metalloproteinases (MMPs) are a family of zincโdependent neutral endopeptidases collectively capable of degrading essentially all matrix components. Elevated levels
Matrix metalloproteinases and their regulators are cardiovascular therapeutic targets
โ Scribed by Friedrich C. Luft
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 152 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0946-2716
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract We have previously reported that human matrix metalloproteinaseโ1 (MMP1) is a __p53__ target gene subject to downโregulation (Sun et al. [1999]: J Biol Chem 274:11535โ11540]. In the present study, we demonstrate that the downโregulation of the human โ83MMP1 promoter fragment by p53 was
## Abstract ## Objective To investigate the role of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in spondylarthropathy (SpA) synovitis. ## Methods Paired samples of synovial biopsy tissue as well as serum and synovial fluid (SF) from 41 patients wit