𝔖 Bobbio Scriptorium
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Matrix metalloproteinases and metastasis

✍ Scribed by David E. Kleiner; William G. Stetler-Stevenson

Book ID
105994637
Publisher
Springer
Year
1999
Tongue
English
Weight
397 KB
Volume
43
Category
Article
ISSN
0344-5704

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πŸ“œ SIMILAR VOLUMES

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Hematogenous metastasis is postulated to involve tumor cell-initiated degradation of basement membrane barriers and underlying connective tissue matrices. Matrix metalloproteinases (MMP) are zinc-dependent endopeptidases that have been implicated in the proteolytic events of tumor cell invasion. Res

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## Abstract Matrix metalloproteinases (MMPs) have been linked to the metastatic potential of tumor cells due to their ability to degrade the extracellular matrix. MMP‐3 (stromelysin‐1) is upregulated in a wide variety of human tumors. We used the MMTV‐PyMT breast cancer model to determine if MMP‐3