𝔖 Bobbio Scriptorium
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Membrane associated matrix metalloproteinases in metastasis

✍ Scribed by Shawn M. Ellerbroek; M. Sharon Stack

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
240 KB
Volume
21
Category
Article
ISSN
0265-9247

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✦ Synopsis

Hematogenous metastasis is postulated to involve tumor cell-initiated degradation of basement membrane barriers and underlying connective tissue matrices. Matrix metalloproteinases (MMP) are zinc-dependent endopeptidases that have been implicated in the proteolytic events of tumor cell invasion. Research has revealed a class of membrane-anchored metalloproteinases (MT-MMPs) and has provided convincing evidence that these enzymes activate latent MMP-2 (72 kDa gelatinase A) on the cell surface. The activation of plasma membrane associated MMP is a potential mechanism for facilitation of cellular metastasis and requires consideration when addressing potential roles of MMPs in tumor progression. This review focuses on potential in vivo regulatory mechanisms of membraneassociated MMP activity in the context of tumor cell interaction with matrix macromolecules.

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