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Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse

✍ Scribed by Leco, Kevin J. ;Harvey, Mark B. ;Hogan, Aileen ;Copeland, Neal G. ;Gilbert, Debra J. ;Jenkins, Nancy A. ;Edwards, Dylan R. ;Schultz, Gilbert A.

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
88 KB
Volume
21
Category
Article
ISSN
0192-253X

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✦ Synopsis

The activity and expression of matrix metalloproteinase-9/gelatinase B (MMP-9), an enzyme implicated in the implantation process in mice, was investigated in normal and parthenogenetic blastocyst outgrowths. Conditioned media from parthenogenetic blastocysts after 4 days of culture had reduced levels of MMP-9 activity compared to conditioned medium from normal outgrowths. Levels of MMP-9 mRNA assayed by reverse transcription-polymerase chain reaction methods were also reduced in parthenogenetic blastocysts compared to normal outgrowths. Genetic mapping studies showed that Mmp9 maps to the distal end of chromosome 2 near the proximal boundary of a region affected by genomic imprinting. Both parental alleles of Mmp9, however, are expressed in 11.5-day embryos derived from interspecific crosses of Mus musculus and Mus spretus. Thus, loss of MMP-9 activity in parthenogenetic blastocysts does not appear to be due to imprinting but, rather, due to a defect of trophoblast giant cell proliferation and differentiation.

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