## Abstract Matrix metalloproteinaseโ2 (MMPโ2) and โ9 (MMPโ9) play an important role in cancer initiation, invasion, and metastasis. The aim of this study was to investigate whether common genetic variants in these two key MMPs are associated with the development and progression of colorectal cance
Matrix metalloproteinase 2 and 9 activity in patients with colorectal cancer liver metastasis
โ Scribed by E. T. Waas; T. Wobbes; R. M. L. M. Lomme; J. DeGroot; T. Ruers; T. Hendriks
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 149 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0007-1323
- DOI
- 10.1002/bjs.4346
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๐ SIMILAR VOLUMES
Degradation of basement membranes is a key step in tumoral invasion, mainly mediated by matrix metalloproteinases (MMPs) and their inhibitors (TIMPs). Since the liver is a main target for metastases from gastrointestinal adenocarcinoma, we have investigated MMP2 and TIMP2 expression by RT-PCR, in si
## Background: Activation of matrix metalloproteinase-2 (mmp-2) has been implicated in the progression, invasion, and metastasis of various cancers, but little information is available with regard to its role in pancreatic carcinoma with poor prognosis. ## Methods: Gelatin zymography was used for