๐”– Bobbio Scriptorium
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Matrix influence on the tumor cell stimulation of fibroblast collagenase production

โœ Scribed by Chitra Biswas

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
430 KB
Volume
28
Category
Article
ISSN
0730-2312

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โœฆ Synopsis

Cocultures of rabbit fibroblasts and mouse B-16 melanoma cells produce increased levels of collagenase against type I collagen. This stimulatory effect was also found when fibroblasts were cultured in conditioned media from tumor cells. However, the level of the stimulatory factor in conditioned media was influenced by matrix deposited by fibroblasts. Thus, conditioned media collected from monolayers of B-16 plated on fibroblast matrix consistently showed high levels of the factor activity. The influence of the matrix on the level of the factor was not removed by treating the fibroblast matrix with collagenase or chondroitinase ABC and was not reproduced by collagen-coated dishes.

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