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Mathematical modeling of mixing in a horizontal rotating tubular bioreactor: “Spiral flow” model

✍ Scribed by B. Šantek; P. Horvat; S. Novak; B. Mayr; A. Moser; V. Marić

Publisher: Springer
Year: 1996
Tongue: English
Weight: 621 KB
Volume: 14
Category: Article
ISSN: 1615-7605
DOI: 10.1007/bf00369917

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✦ Synopsis

A horizontal rotating tubular bioreactor (HRTB) was designed as a combination of a "thin-layer bioreactor" and a "biodisc" reactor whose interior was divided by O-ring shaped partition walls. For the investigation of mixing in K1 Wm-2 K 1 HRTB the temperature step method was applied. Temperature changes in the bioreactor were monitored by six Pt-100 sensors K2

Wm-2 K 1 (tg0 response time 0.08 s and resolution 0.002 ~ which were connected with an interface unit and a personal computer. In L m this work a modified "tank in series" concept was used to ms kg establish a mathematical model. The heat balance of the model n rain 1 compartments was established according to the physical model ns and the "spiral flow" pattern. Numerical integration was done N1 by the Runge-Kutt~Fehlberg method. The mathematical

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