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Maternal serum human chorionic gonadotrophin levels in systemic lupus erythematosus and antiphospholipid syndrome

โœ Scribed by Ron Maymon; Howard Cuckle; Indera K. Sehmi; Arie Herman; Dan Sherman

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
49 KB
Volume
21
Category
Article
ISSN
0197-3851

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โœฆ Synopsis

Maternal serum human chorionic gonadotrophin (hCG) levels were measured during the second and the third trimesters of pregnancy in patients with either systemic lupus erythematosus (SLE) or primary antiphospholipid syndrome (APS). All results were expressed in multiples of the gestation-speciยฎc normal medians (MoM). The median MoM level in 17 samples from SLE patients was 1.48 compared with 0.79 MoM in 99 controls of similar gestation ( p<0.002, Wilcoxon Rank sum test). In contrast the median MoM level in 19 samples from primary APS patients was only 1.14. These preliminary ยฎndings should be further studied to evaluate the implications for Down syndrome screening, detection of SLE cases during pregnancy and the prediction of adverse outcome in SLE gestations.

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