𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Maternal periconceptional smoking and alcohol consumption and risk for select congenital anomalies

✍ Scribed by Jagteshwar Grewal; Suzan L. Carmichael; Chen Ma; Edward J. Lammer; Gary M. Shaw

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
92 KB
Volume
82
Category
Article
ISSN
1542-0752

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

BACKGROUND: This study examined the association between maternal smoking and alcohol use (including binge drinking) during the periconceptional period (i.e., 2 months before through 2 months after conception) and the risk of orofacial clefts, NTDs, and conotruncal heart defects in offspring. METHODS: Data were drawn from a population‐based case‐control study of fetuses and live‐born infants among a cohort of California births between July 1999 and June 2003. The 1,355 cases comprised of 701 orofacial clefts, 337 NTDs, and 323 conotruncal heart defects. Information on smoking and alcohol consumption was obtained via telephone interviews with mothers of 1,355 (80% of eligibles) cases and 700 (77% of eligibles) nonmalformed, live‐born controls. RESULTS: Maternal smoking of five cigarettes or less per day was associated with reduced risks of NTDs (OR 0.7; 95% CI: 0.3, 1.4), whereas the risk associated with higher cigarette consumption was lower for conotruncal heart defects (OR 0.5; 95% CI: 0.2, 1.2). Maternal intake of alcohol less than 1 day per week was associated with a 1.6‐ to 2.1‐fold higher risk of NTDs (95% CI: 0.9, 2.6), d‐transposition of the great arteries (95% CI: 1.1, 3.2), and multiple cleft lip with or without cleft palate (CLP) (95% CI: 0.8, 4.5). Risks associated with more frequent alcohol intake were 2.1 for NTDs (95% CI: 1.1, 4.0) and 2.6 for multiple CLP (95% CI: 1.1, 6.1). CONCLUSIONS: This study observed that maternal alcohol intake increased the risk for d‐transposition of the great arteries, NTDs, and multiple CLP in infants. By contrast, smoking was associated with a lower risk of NTDs and conotruncal heart defects. Birth Defects Research (Part A), 2008. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Maternal periconceptional exposure to ci
Maternal periconceptional exposure to cigarette smoking and alcohol consumption and congenital diaphragmatic hernia
✍ Kristin M. Caspers; Cristiana Oltean; Paul A. Romitti; Lixian Sun; Barbara R. Po 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 112 KB 👁 1 views

## Abstract **BACKGROUND:** Congenital diaphragmatic hernia (CDH) is a major birth defect that occurs when abdominal organs herniate through a diaphragmatic opening into the thoracic cavity and is associated with high mortality (>50%). The etiology of CDH is not well understood. **METHODS:** Using

Maternal periconceptional alcohol consum
Maternal periconceptional alcohol consumption and risk for conotruncal heart defects
✍ Suzan L. Carmichael; Gary M. Shaw; Wei Yang; Edward J. Lammer 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 69 KB 👁 1 views

## Abstract ## BACKGROUND In this study we investigated whether the risk of delivering infants with conotruncal heart defects was increased among mothers who consumed alcohol during the periconceptional period (i.e., 1 month before conception to 3 months after conception). ## METHODS Data were o

Maternal corticosteroid use and risk of
Maternal corticosteroid use and risk of selected congenital anomalies
✍ Carmichael, Suzan L.; Shaw, Gary M. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 11 KB 👁 2 views

Evidence for the teratogenicity of corticosteroids in humans is limited and has resulted in inconsistent recommendations regarding their use during early pregnancy. We examined the association between women's corticosteroid use during the periconceptional period (1 month before to 3 months after con

Risk for congenital anomalies associated
Risk for congenital anomalies associated with different sporadic and daily doses of alcohol consumption during pregnancy: A case–control study
✍ Maria Luisa Martínez-Frías; Eva Bermejo; Elvira Rodríguez-Pinilla; Jaime Luis Fr 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 2 views

## Abstract ## BACKGROUND The classic clinical criteria for the diagnosis of fetal alcohol syndrome (FAS) include a “characteristic” facial appearance, pre‐ and postnatal growth deficiency, microcephaly, mental retardation, and occasional major malformations. However, diagnostic constraints, espec

Selected gene polymorphisms and their in
Selected gene polymorphisms and their interaction with maternal smoking, as risk factors for gastroschisis
✍ Claudine P. Torfs; Roberta E. Christianson; David M. Iovannisci; Gary M. Shaw; E 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB 👁 2 views

## Background: Gastroschisis is a severe birth defect in which the infant is born with a portion of the intestines extruding through a small tear in the abdominal wall, usually to the right of the umbilical cord. its etiology is unknown, but the prevailing hypothesis is that it results from a vascu