## Background: This cohort study examines the possible association between maternal alcohol intake, including binge drinking, during pregnancy, and the subsequent risk of having a child with an isolated congenital heart defect and, more specifically, with the isolated form of ventricular septal def
β¦ LIBER β¦
Maternal homozygosity for the commonMTHFR mutation as a potential risk factor for offspring with limb defects
β Scribed by Shashi, Vandana ;Rickheim, Amy ;Pettenati, Mark J.
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 84 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0148-7299
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## Abstract Abnormal folate/homocysteine metabolism due to polymorphisms in genes involved in this pathway has been implicated as an etiologic factor in Down syndrome (DS). This caseβcontrol study aimed to evaluate the effect of maternal C677T and A1298C polymorphisms of the methylenetetrahydrofola