Maternal alcohol drinking pattern during pregnancy and the risk for an offspring with an isolated congenital heart defect and in particular a ventricular septal defect or an atrial septal defect
✍ Scribed by Katrine Strandberg-Larsen; Lise Skrubbeltrang Skov-Ettrup; Morten Grønbæk; Anne-Marie Nybo Andersen; Jørn Olsen; Janne Tolstrup
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 90 KB
- Volume
- 91
- Category
- Article
- ISSN
- 1542-0752
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✦ Synopsis
Background:
This cohort study examines the possible association between maternal alcohol intake, including binge drinking, during pregnancy, and the subsequent risk of having a child with an isolated congenital heart defect and, more specifically, with the isolated form of ventricular septal defect (vsd) or of an atrial septal defect (asd).
Methods:
Participants were 80,346 pregnant women who were enrolled into the danish national birth cohort in 1996-2002 and gave birth to a live-born singleton without any chromosome anomalies. twice during pregnancy these women were asked about their intake of alcohol. few (if any) women with an excessive/abusive intake of alcohol were enrolled into the danish national birth cohort.
Results:
Through linkage with the national hospital discharge registry, we identified 477 infants with a diagnosis of isolated congenital heart defect registered at any time during their first 3½-years of life; they included 198 infants with a vsd and 145 with an asd. neither the number of episodes of binge drinking nor binge drinking during three different developmental periods was associated with vsd or asd. women drinking ½-1½, 2, and 3+ drinks of alcohol per week had adjusted prevalence ratios of delivering an infant with a vsd of 1.22 (95% ci = 0.90-1.66); 1.38 (95% ci = 0.83-2.28); and 1.10 (95% ci = 0.54-2.23), respectively. the test for trend was 0.29.
Conclusions:
Prenatal exposure to low-to-moderate levels of alcohol on a weekly basis or occasional binge drinking during the early part of pregnancy was not statistical significantly associated with the prevalence of isolated vsd and asd in offspring.