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Maternal-fetal disparity in HLA class II alloantigens and the pregnancy-induced amelioration of rheumatoid arthritis

✍ Scribed by J.L. Nelson; K.A. Hughes; A.G. Smith; B.B. Nisperos; A.M. Branchaud; J.A. Hansen


Book ID
118892337
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
271 KB
Volume
45
Category
Article
ISSN
0020-7292

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## Objective: To evaluate the contributions of hla-dq and -dr polymorphisms to susceptibility to rheumatoid arthritis (ra) in a population in southern spain, and to compare the value of the shared epitope (se) and ra protection (rap) models in accounting for the hla class ii region's contribution t

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Objective. In Northern Europeans, rheumatoid arthritis (RA) is strongly associated with a relatively conserved pentapeptide sequence of HLA-DRP found notably in the HLA-DR4 subtypes Dw4 and Dw14 and in DRl. A previous serologic study of HLA class I1 polymorphism in a Greek population with RA failed