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Mast cell-mediated downregulation of Bcl-2 expression triggers endothelial cell apoptosis in vitro

✍ Scribed by S. Lätti; N. Shiota; M. Leskinen; Y. Wang; P. Kovanen; K. Lindstedt

Book ID
119435175
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
142 KB
Volume
151
Category
Article
ISSN
0021-9150

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## Abstract Degranulated mast cells are present in the subendothelial space of eroded (de‐endothelialized) coronary atheromas. Upon degranulation, mast cells secrete into the surrounding tissue an array of preformed and newly synthesized mediators, including proapoptotic molecules, such as chymase