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Mass spectrometry of some 10β-Fluoro-1,4-estradien-3-oxo steroids

✍ Scribed by D. D. Desmarteau; G. Resnati; R. Seraglia; P. Traldi

Book ID: 102560363
Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 383 KB
Volume: 29
Category: Article
ISSN: 1076-5174
DOI: 10.1002/oms.1210290107

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✦ Synopsis

The mass spectrometric behavior of some lOfMuoro-l,4-estradiene-3-oxo steroids under two different ionization conditions (electron inpact and fast atom bombardment) was studied with the aid of mass-analyzed ion kinetic energy spectroscopy. The influence of fluorine in the fragmentation pattern was investigated by comparison with the behavior of 10-methyl analogs. In particular, the presence of fluorine at position 10 seems to reflect the weakening of C(9)-C(10) bond. Further, when an acyloxy moiety is present at position 17, the primary ring cleavages typical of steroids become disfavored and fragment ions related to the acyloxy substituents are detected.

tion patterns was investigated by comparison with the behavior of 10-methyl analogs (5 and 6). 0 & 1 2 4 0 II 0 -c --El 0 ' @ 3 P 5 0 -C -Me 1 0 dP 6

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