Marker chromosome 14q+ in two non-Burkitt lymphomas
β Scribed by E. L. Prigogina; E. W. Fleischman
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 584 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0340-6717
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β¦ Synopsis
Marker chromosome 14q+, similar to the specific marker of the Burkitt lymphoma, was revealed in all malignant blood cells of a patient with generalized lymphosarcoma, in all lymph node cells, and in a part of the blood cells of a patient with chronic lymphocytic leukaemia. Possible causes of this similarity are discussed.
π SIMILAR VOLUMES
## Abstract Chromosome studies were performed on malignant cells obtained from 27 patients with nonβBurkitt lymphomas. A marker chromosome affecting the long arm of No. 14 (14q+) was the single most frequent abnormality and was noted in 17 of these patients. The frequency of the 14q+ marker varied
The cytogenetic findings by G-banding in two histiocytic lymphomas are described. Both tumors had a stemline with a 14q+ marker. The origin of the extra segment on No. 14 was determined, and it was different in the two cases. These observations, and those from non-Burkitt lymphomas with 14q+ markers
Cytogenetic, in situ hybridization, and molecular studies were performed in a case of T-cell-rich B-cell lymphoma. Demonstration of Ig gene rearrangements for both heavy and light chains confirmed the B-lineage restriction of the neoplastic cell population. Moreover, as expected in B-cell malignanci
## Abstract Chromosome analysis using banding staining techniques was carried out on cells from a Bβcell acute lymphocytic leukemia (ALL) of the Burkitt type and a case of nonβendemic Burkitt lymphoma presenting as ALL. In both patients a marker chomoβsome 14q+ was found which was morphologically i