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14Q+ CHROMOSOME MARKER IN A T-CELL-RICH B-CELL LYMPHOMA

✍ Scribed by LA STARZA, ROBERTA; AVENTIN, ANA; FALZETTI, DANIELA; STUL, MICHEL; MARTELLI, MASSIMO F.; FALINI, BRUNANGELO; MECUCCI, CRISTINA

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
517 KB
Volume
178
Category
Article
ISSN
0022-3417

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✦ Synopsis

Cytogenetic, in situ hybridization, and molecular studies were performed in a case of T-cell-rich B-cell lymphoma. Demonstration of Ig gene rearrangements for both heavy and light chains confirmed the B-lineage restriction of the neoplastic cell population. Moreover, as expected in B-cell malignancies, all abnormal karyotypes showed a 14q+ chromosome marker involving 14q32. The origin of the extra material on the derivative 14q+, as defined by chromosome painting with a library for chromosome 11, and Southern blotting for c-myc and bcl-2 rearrangements, remains unknown.

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