A biological role for deletions in chromosomal band 13q14 in mantle cell and peripheral t-cell lymphomas?

✍ Scribed by Andreas Rosenwald; German Ott; Ann Katrin Krumdiek; Martin H. Dreyling; Tiemo Katzenberger; Jörg Kalla; Silke Roth; M. Michaela Ott; Hans Konrad Müller-Hermelink

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 171 KB
• Volume: 26
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/(sici)1098-2264(199911)26:3<210::aid-gcc4>3.0.co;2-j

✦ Synopsis

Structural aberrations of chromosomal band 13q14 are frequent in B-cell chronic lymphocytic leukemia (B-CLL) and target a putative tumor suppressor gene in the genomic region between the RB1 gene and the genetic marker D13S25. Recently, it has been suggested that alterations of this particular region might also be of relevance for the pathogenesis of mantle cell lymphomas (MCL). We applied dual-color fluorescence in situ hybridization (FISH) using probes for the RB1 and/or D13S25 loci and screened a total of 236 B-and T-cell non-Hodgkin's lymphomas (NHL) for deletions occurring in this genomic region. In MCL, the high rate (12/32; 38%) of hemizygous deletions and especially a deletion pattern similar to B-CLL in four of the cases provide further evidence that a substantial proportion of MCL cases may share a common way of pathogenesis with B-CLL. In other B-cell NHL, the frequency of allelic loss affecting 13q14 was overall low. However, the finding of 13q14 microdeletions in seven cases without detectable alterations of chromosome 13 at G-banding analysis might indicate a possible involvement of this genetic region also for the lymphomagenesis of single cases of B-cell NHL other than B-CLL and MCL. In T-cell NHL, allelic loss at 13q14 was encountered in three of 13 peripheral T-NHL, NOS. Taking into account the very limited cytogenetic data yet available in this entity, our series provides further evidence that 13q14 changes might represent one of the most frequent genetic abnormalities in T-cell NHL.