Ammonia is the principal neurotoxin implicated in the pathogenesis of hepatic encephalopathy, and astrocytes are the neural cells predominantly affected in this condition. Astrocyte swelling (cytotoxic edema) represents a critical component of the brain edema in acute form of hepatic encephalopathy
Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes
β Scribed by Kakulavarapu V Rama Rao; Arumugam R Jayakumar; Xiaoying Tong; Veronica M Alvarez; Michael D Norenberg
- Book ID
- 119907408
- Publisher
- BioMed Central
- Year
- 2010
- Tongue
- English
- Weight
- 836 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1742-2094
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Hepatic encephalopathy (HE) is a major neurological complication in patients with severe liver disease. While the pathogenesis of HE is unclear, elevated blood and brain ammonia levels are believed to be major etiological factors, and astrocytes appear to be the primary target of its to
## Abstract Hyposmolarity (β30%) in cultured cerebellar astrocytes raised cytosolic Ca^2+^ concentration ([Ca^2+^]~i~) from 160 to 400 nM and activated the osmosensitive taurine release (OTR) pathway. Although OTR is essentially [Ca^2+^]~i~βindependent, further increase in [Ca^2+^]~i~ by ionomycin