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Marked differences in the frequency of microsatellite instability in gastric cancer from different countries

✍ Scribed by Antonia R Sepulveda; Ana C Santos; Yoshio Yamaoka; Ling Wu; Oscar Gutierrez; Jong G Kim; David Y Graham

Book ID: 119396636
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 88 KB
Volume: 94
Category: Article
ISSN: 0002-9270
DOI: 10.1016/s0002-9270(99)00509-2

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i