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Marine neuroprotectants activating the alpha-secretase pathway: A novel approach for the treatment of Alzheimer's disease

✍ Scribed by Dominguez, Juan M.; Garcia-Palomero, Esther; Usán, Paola; García, Pablo; de Austria, Celia; Saiz, Gonzalo; Pérez, Maria A.; Sánchez-Quesada, Jorge; Dorronsoro, Isabel; Castro, Ana; Medina, Miguel

Book ID
122602991
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
44 KB
Volume
5
Category
Article
ISSN
1552-5260

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## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we