✦ LIBER ✦

Marginal zone B cells in lymphocyte activation and regulation

✍ Scribed by Thiago Lopes-Carvalho; Jeremy Foote; John F Kearney

Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 401 KB
Volume: 17
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2005.04.009

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✦ Synopsis

Marginal zone (MZ) B cells, together with other strategically located innate cells, constitute the first line of defense against blood-borne microorganisms, viruses and toxins in the spleen. Their fast and efficient protective antibody responses are well characterized; however, much less is known of their interactions with other cell types during immune responses. Recent work has demonstrated that MZ B cells can directly activate T cells; and MZ B cells also interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses.

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