Mapping the chromosome instability function of the SV40 T antigen
β Scribed by F.Andrew Ray; Mary Jo Waltman; Paul M. Kraemer
- Book ID
- 119106021
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 118 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0165-4608
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## Abstract The expression of the nuclear SV40βinduced T antigen was measured by micro fluorimetry on individual, asynchronously growing SV40βtransformed cells which had been stained with hamster Tβantiserum by the indirect immunofluorescence method. The same individual cells were first measured fo
The SV40 T antigen causes numerical (aneuploidy) and structural (aberrations) chromosome damage when expressed in human diploid fibroblasts. This chromosome damage precedes the acquisition of neoplastic traits such as anchorage independence, colony formation in reduced serum growth factors, immortal