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Binding of an SV40 T antigen-related protein to the DNA of SV40 regulatory mutants

✍ Scribed by McKay, R.; DiMaio, D.


Book ID
109722181
Publisher
Nature Publishing Group
Year
1981
Tongue
English
Weight
498 KB
Volume
289
Category
Article
ISSN
0028-0836

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Structure-based design of a disulfide-li
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With the aim of forming the β€˜lock-washer’ conformation of the origin-binding domain of SV40 large T antigen in solution, using structure-based analysis an intermolecular disulfide bridge was engineered into the origin-binding domain to generate higher order oligomers in solution. The 1.7β€…Γ… resolutio