A detailed analysis of loss of heterozygosity (LOH) in breast cancers was performed with 11 microsatellite markers on the long arm of chromosome 21. Among the 142 tumors examined, 44 (31%) showed LOH at one or more loci. Peak LOH frequency was observed on band 21q21. Deletion mapping identified a ne
โฆ LIBER โฆ
Mapping of Target Regions of Allelic Loss in Primary Breast Cancers to 1-cM Intervals on Genomic Contigs at 6q21 and 6q25.3
โ Scribed by Utada, Yoshihito ;Haga, Shunsuke ;Kajiwara, Tetsuro ;Kasumi, Fujio ;Sakamoto, Goi ;Nakamura, Yusuke ;Emi, Mitsuru
- Book ID
- 108581891
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2000
- Tongue
- English
- Weight
- 139 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0910-5050
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Allelic losses on chromosome arm 22q are frequently observed in human meningiomas and in carcinomas of the colon, ovary, and breast. Among 140 primary breast cancers we examined for loss of heterozygosity (LOH) at 16 polymorphic loci on the long arm of chromosome 22, 56 (40%) showed LOH for at least