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Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families

✍ Scribed by Mahtani, Melanie M.; Widén, Elisabeth; Lehto, Markku; Thomas, Jeffrey; McCarthy, Mark; Brayer, James; Bryant, Barbara; Chan, Gayun; Daly, Mark; Forsblom, Carol


Book ID
109917956
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
596 KB
Volume
14
Category
Article
ISSN
1061-4036

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Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec