Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role

Linkage analysis of the human insulin re

Linkage analysis of the human insulin receptor gene in Type 2 (non-insulin-dependent) diabetic families and a family with maturity onset diabetes of the young

✍ S. O'Rahilly; R. C. Trembath; P. Patel; D. J. Galton; R. C. Turner; J. S. Wainsc 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 656 KB

The possibility of linkage between the human insulin receptor gene locus and diabetes was examined in three Type 2 (non-insulin-dependent) diabetic families and one family with maturity onset diabetes of the young. Insulin receptor gene haplotypes were established using BglII, Rsal and Sstl restrict