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MAPK/ERK signaling mediates melatonin-induced neuroendocrine differentiation in prostate cancer cells

โœ Scribed by R.M. Sainz; D. Hevia; I. Quiros; J.C. Mayo

Book ID
119598737
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
85 KB
Volume
6
Category
Article
ISSN
1359-6349

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โœ Spiotto, Michael T.; Chung, Theodore D.K. ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 653 KB

## Background: In the human prostate cancer cell line lncap, interleukin (il)-6 has been shown to regulate both growth and neuroendocrine (ne) differentiation. we recently observed that il-6 mediated growth arrest in lncap by activating stat 3. since differentiation and growth arrest are often asso