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MAP kinase signalling cascades and transcriptional regulation

✍ Scribed by Shen-Hsi Yang; Andrew D. Sharrocks; Alan J. Whitmarsh

Book ID: 119241489
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 702 KB
Volume: 513
Category: Article
ISSN: 0378-1119
DOI: 10.1016/j.gene.2012.10.033

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## Abstract Tyrosine kinase growth factor receptors activate MAP kinase by a complex mechanism involving the SH2/3 protein Grb2, the exchange protein Sos, and Ras. The GTP‐bound Ras protein binds to the Raf kinase and initiates a protein kinase cascade that leads to MAP kinase activation. Three MAP