MAP kinase cascades in elicitor signal transduction
โ Scribed by K. Suzuki
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 158 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0918-9440
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Some protein kinases operate in more than one mitogen-activated protein-kinase (MAPK) cascade. We here address the question whether specificity of the cascades necessitates physical sequestration of these "promiscuous" kinases (e.g. by binding to scaffolds). A model is constructed, in which two MAPK
We have studied in cultured rat astroglial cells MAP kinases, known for their role in intracellular signal transduction. The MAP kinase activity was stimulated by growth factors (FGFb, FGFa, EGF, PDGF, and IGFl), by a phorbol ester (TPA) activating-protein kinase C (PKC), by a neuropeptide (endothel