✦ LIBER ✦

Selectivity in Overlapping MAP Kinase Cascades

✍ Scribed by OSCAR J.G. SOMSEN; MARCO SIDERIUS; FLORIAN F. BAUER; JACKY L. SNOEP; HanS V. WESTERHOFF

Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 239 KB
Volume: 218
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.2002.3082

No coin nor oath required. For personal study only.

✦ Synopsis

Some protein kinases operate in more than one mitogen-activated protein-kinase (MAPK) cascade. We here address the question whether specificity of the cascades necessitates physical sequestration of these "promiscuous" kinases (e.g. by binding to scaffolds). A model is constructed, in which two MAPK cascades depend on a single MAP-kinase kinase that is not sequestered in two subpopulations. We show that in this model selective signal transduction is possible provided that there is an additional interaction at the MAP-kinase level, there is no simultaneous activation of more than one response by either signal. We discuss a number of additional interactions that can generate the selectivity, as well as some kinetic features by which this mechanism may be recognized experimentally.

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