✦ LIBER ✦

Many cells in rat bone marrow have cell-surface Thy-1 antigen

✍ Scribed by A. F. Williams

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 337 KB
Volume: 6
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830060716

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✦ Synopsis

Abstract

Thy‐1.1 and Thy‐1 xenoantigenic determinants were detected at the cell surface of many rat bone marrow cells. The absorptive capacity of bone marrow cells was 6–10 % of that of thymocytes for Thy‐1 antigenic determinants, and 30–45 % of rat bone marrow cells were specifically labeled with anti‐Thy‐1 antibody as detected by autoradiography. Thus, while mice and rats are similar in having large amounts of Thy‐1 in brain and thymocytes, they differ in that the rat lacks the antigen in most peripheral T cells and expresses it in a large number of bone marrow cells; the opposite is true in the mouse.

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