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Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis

✍ Scribed by Byung Ok Lee; Katsuhiko Ishihara; Kakuro Denno; Yoshiko Kobune; Motoyuki Itoh; Osamu Muraoka; Tsuneyasu Kaisho; Takeshi Sasaki; Takahiro Ochi; Toshio Hirano

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 815 KB
Volume: 39
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780390414

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. Bone marrow stromal cell antigen I (BST-1) is a novel glycosyl phosphatidylinositolanchored ectoenzyme, which is overexpressed on bone marrow stromal and synovial cell lines derived from patients with rheumatoid arthritis (RA). To investigate the pathophysiologic roles of BST-I in RA, we established an enzyme-linked immunosorbent assay (ELISA) system to detect the soluble form of BST-1 (sBST-1) and examined levels of sBST-1 in the sera of RA patients.

Methods. Concentrations of sBST-1 in sera from healthy donors and from patients with RA, osteoarthritis, Sjogren's syndrome, and systemic lupus erythematows were measured with the ELISA.

Results. In 7% of the RA patient samples (10 of 143), concentrations of serum sBST-1 were higher (-30-50-fold) than in non-RA samples. Serum sBST-1 concentrations showed no correlation with age, Creactive protein level, or rheumatoid factor level. All RA patients with high concentrations of serum sBST-1 had severe disease with involvement of several large joints.

Conclusion. We believe the measurement of serum sBST-I may have prognostic value, but further

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