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Mannose 6-Phosphate Receptors: Potential Mediators of Germ Cell-Sertoli Cell Interactions

✍ Scribed by DEBORAH A. O'BRIEN; CHRISTOPHER A. GABEL; JEFFREY E. WELCH; E. M. EDDY

Book ID: 119866010
Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 765 KB
Volume: 637
Category: Article
ISSN: 0890-6564
DOI: 10.1111/j.1749-6632.1991.tb27320.x

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## Abstract The mannose 6‐phosphate/insulin‐like growth factor II receptor (M6P/IGF2R) mediates biosynthetic sorting and endocytosis of various factors that impinge on the proliferation, migration and invasiveness of tumour cells. The gene encoding M6P/IGF2R is frequently lost or mutated in a wide