Specific Mannose-6-Phosphate Receptor-Independent Sorting of Pro-Cathepsin D in Breast Cancer Cells
✍ Scribed by Françoise Capony; Thomas Braulke; Christian Rougeot; Sylvie Roux; Philippe Montcourrie; Henri Rochefort
- Book ID
- 115601886
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 912 KB
- Volume
- 215
- Category
- Article
- ISSN
- 0014-4827
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The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF-IIR) is thought to act as a suppressor of tumor growth by binding the mitogenic peptide IGF-II and modulating its extracellular levels via degradation. This receptor has been found to be absent or nonfunctional in a high proport
The mannose-6-phosphate/insulin-like growth factor 2 receptor (Man-6-P/IGFII receptor) is involved in lysosomal enzyme sorting, IGFII degradation and pro-TGFbeta activation. Genetic alterations in hepatocarcinomas and a few breast cancers suggest that this receptor behaves as a tumor suppressor. Mor