Mannich-type reactions are powerful methods for the efficient synthesis of b-amino carbonyl compounds that are valuable intermediates for the construction of natural products, b-peptides, and peptidomimetics. For the efficient steric steering of Mannich reactions a method was developed that consists
Mannich Reactions with Amino Alcohols
✍ Scribed by Christian Schmidt; Thomas Straub; Dezsö Falàbu; Erich F. Paulus; Elina Wegelius; Erkki Kolehmainen; Volker Böhmer; Kari Rissanen; Walter Vogt
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 485 KB
- Volume
- 2000
- Category
- Article
- ISSN
- 1434-193X
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📜 SIMILAR VOLUMES
As a result of an extensive delocalization of charge and a unique covalent structure, the cation has, in CH 3 OCH 2 ' e †ect, the character of an ambident electrophile. This cation can, on the one hand, be considered to be a classical electrophile. On the other hand, it may be considered to be a fac
## Abstract The first primary amine‐containing amino acid‐catalyzed __anti__‐Mannich reactions of dihydroxyacetone and acyclic dihydroxyacetone derivatives with a variety of imines have been developed. This approach complements proline‐based strategies in the preparation of amino sugars.