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Mannich Reactions with Amino Alcohols

✍ Scribed by Christian Schmidt; Thomas Straub; Dezsö Falàbu; Erich F. Paulus; Elina Wegelius; Erkki Kolehmainen; Volker Böhmer; Kari Rissanen; Walter Vogt


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
485 KB
Volume
2000
Category
Article
ISSN
1434-193X

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As a result of an extensive delocalization of charge and a unique covalent structure, the cation has, in CH 3 OCH 2 ' e †ect, the character of an ambident electrophile. This cation can, on the one hand, be considered to be a classical electrophile. On the other hand, it may be considered to be a fac

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## Abstract The first primary amine‐containing amino acid‐catalyzed __anti__‐Mannich reactions of dihydroxyacetone and acyclic dihydroxyacetone derivatives with a variety of imines have been developed. This approach complements proline‐based strategies in the preparation of amino sugars.