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Mannich Reaction of 2,5-Xylenol, Morpholine and Formaldehyde

✍ Scribed by Hansell, David P.


Book ID
102365593
Publisher
Wiley (John Wiley & Sons)
Year
1978
Weight
161 KB
Volume
1978
Category
Article
ISSN
0074-4617

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✦ Synopsis


Abstract

Reaction of 2,5‐xylenol with morpholine and formaldehyde in 2‐propanol affords in 65% yield a mixture of the p‐ and o‐substituted Mannich derivatives 1 and 3 together with a minor amount of the o,p‐disubstituted Mannich compound 2.


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Mechanism of the mannich reaction involv
✍ J.H. Burckhalter; J.N. Wells; William J. Mayer πŸ“‚ Article πŸ“… 1964 πŸ› Elsevier Science 🌐 French βš– 262 KB

The Mannich reaction plays an essential role in the biosynthesis2 and laboratory synthesis of important nitrogenous substances. 3 In spite of the importance of the reaction, a satisfactory mechanism has not been elucidated. Several different mechanisms probably operate, depending upon pH and the nat