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Mannan-binding lectin associated serine protease 2 (MASP-2) activates prothrombin directly and initiates low-level clotting

✍ Scribed by Anders Krarup; Krishnan Hajela; Russell Wallis; Julia S. Presanis; Peter Gal; Robert B. Sim


Book ID
116756053
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
75 KB
Volume
44
Category
Article
ISSN
0161-5890

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## Abstract The lectin pathway of the complement system is activated when Mannan‐binding lectin (MBL) in complex with MASP‐2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease. The present s