Manipulation of cell cycle kinetics: Influence on the cytotoxicity of doxorubicin in human breast cancer cells
โ Scribed by BONTENBAL, M; SIEUWERTS, A; PETERS, H; SONNEVELD, P; FOEKENS, J; KLIJN, J
- Book ID
- 122456487
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 416 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0960-0760
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๐ SIMILAR VOLUMES
Cell kinetic parameters were determined in 32 patients with breast cancer following intravenous [3H]thymidine injection. The mean labelling index (LI) was 8.6, range 1.2 to 24.1. The LI increased significantly with increased stage of disease. The highest values were noted in patients with chest wall
## Abstract The antineoplastic agent doxorubicin inhibits cell growth through mechanisms that include an interaction with iron, resulting in the generation of cytotoxic reactive oxygen species (ROS). Prior studies have shown that the wildโtype hemochromatosis gene (wt HFE) may downregulate iron upt