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Modulation of doxorubicin cytotoxicity by resveratrol in a human breast cancer cell line

โœ Scribed by Abdel-Moneim M Osman, Hadeel M Bayoumi, Sameer E Al-Harthi, Zoheir A Damanhouri, Mohamed F ElShal

Book ID
119900741
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
385 KB
Volume
12
Category
Article
ISSN
1475-2867

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## Abstract The antineoplastic agent doxorubicin inhibits cell growth through mechanisms that include an interaction with iron, resulting in the generation of cytotoxic reactive oxygen species (ROS). Prior studies have shown that the wildโ€type hemochromatosis gene (wt HFE) may downregulate iron upt