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Manganese-enhanced MRI of salivary glands and head and neck tumors in living subjects

✍ Scribed by Mukund Seshadri; Allison Hoy

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
288 KB
Volume
64
Category
Article
ISSN
0740-3194

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✦ Synopsis

Manganese-enhanced MRI has previously been used for visualization of brain architecture and functional mapping of neural pathways. The present work investigated the potential of manganese-enhanced MRI for noninvasive imaging of salivary glands in living subjects. Marked shortening of T 1 was observed in salivary glands of naı ¨ve mice (n 5 5) 24-48 h after systemic administration of MnCl 2 (0.4 mmol/kg, intraperitoneally). Three-dimensional MR microscopy confirmed selective contrast enhancement of salivary gland tissues post-MnCl 2 injection. Ectopic and orthotopic head and neck tumor xenografts also showed an increase in R 1 at 24 h following MnCl 2 injection (0.2 mmol/kg, intraperitoneally). However, tumor enhancement was minimal compared to salivary gland tissue. Salivary gland R 1 values were lower in mice bearing orthotopic head and neck tumors compared to naı ¨ve mice. These results demonstrate, for the first time, the usefulness of manganese-enhanced MRI in the visualization of salivary glands and head and neck tumors in vivo. Magn Reson Med 64:902-906, 2010. V

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