Manganese-Enhanced cardiac MRI (MEMRI) tracks long-termin vivosurvival and restorative benefit of transplanted human Amnion-Derived Mesenchymal Stem Cells (hAMSC) after porcine ischemia-reperfusion injury

Manganese-enhanced MRI detects live huma

Manganese-enhanced MRI detects live human amnion-derived mesenchymal stem cells in vivo after transplantation and restoration of myocardial function in a pig ischemia-reperfusion injury model

✍ Rajesh Dash; Ildiko Toma; Fumiaki Ikeno; Jennifer K Lyons; Shahriar Heidary; Mar 📂 Article 📅 2012 🏛 BioMed Central 🌐 English ⚖ 425 KB

Human Amnion-derived Mesenchymal Stem Cells (hAMSCs) were transplanted into the infarct and periinfarct regions of a pig ischemia-reperfusion model. The hAMSC therapy improved cardiac systolic function post-MI, compared to control animals, and Cardiac MRI with Manganese-Enhanced MRI (MEMRI) was able