Manganese-enhanced MRI detects live human amnion-derived mesenchymal stem cells in vivo after transplantation and restoration of myocardial function in a pig ischemia-reperfusion injury model
✍ Scribed by Rajesh Dash; Ildiko Toma; Fumiaki Ikeno; Jennifer K Lyons; Shahriar Heidary; Marie-Claude Parent; INing E Wang; Xiaohu Ge; Jaehoon Chung; Justin Lam; Paul J Kim; Kaori Nakagawa; Svetlana Lyalina; Grace Do; Robert C Robbins; Michael V McConnell; Alan Yeung; Phillip Harnish; Phillip C Yang
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 425 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1097-6647
No coin nor oath required. For personal study only.
✦ Synopsis
Human Amnion-derived Mesenchymal Stem Cells (hAMSCs) were transplanted into the infarct and periinfarct regions of a pig ischemia-reperfusion model. The hAMSC therapy improved cardiac systolic function post-MI, compared to control animals, and Cardiac MRI with Manganese-Enhanced MRI (MEMRI) was able to detect increased CNR from live populations of hAMSCs within infarct and peri-infarct zones, as confirmed by human nuclear antigen (hNA) immunostaining.