Management of patients with small cell carcinoma and the syndrome of ectopic corticotropin secretion
β Scribed by Frances A. Collichio; Paul D. Woolf; Martin Brower
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 612 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
From 1976 to 1980,18 of the 250 patients (7%) seen with small cell carcinoma of the lung had clinically evident inappropriate secretion of antidiuretic hormone (ADH). Hyponatremia was usually severe (1 16 f 7 meq/l), and eight patients showed symptoms of water intoxication at the time of diagnosis.
Small cell carcinoma of the lung is the tumor most commonly associated with ectopic ACTH production and hypercortisolism. The relationship between this paraneoplastic endocrine syndrome and the clinical course of the tumor i s examined in this review of patients with the ectopic ACTH syndrome and sm