Graft-versus-host disease (GVHD) after liver transplantation is rare but associated with a very high mortality (over 85%). Most treatments focus on increasing immunosuppression, addition of antibody preparations such as OKT3 and antithymocyte globulin to eliminate the donor lymphocytes, and supporti
Management of acute graft-versus-host disease
โ Scribed by Andrea Bacigalupo
- Book ID
- 108674185
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 542 KB
- Volume
- 137
- Category
- Article
- ISSN
- 0007-1048
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Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of allogeneic bone marrow transplantation (BMT). The pathophysiology of acute GVHD is complex and can be conceptualized to be a three-step process based on murine studies. In step 1, the conditioning regimen le