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Mammary gland development is delayed in mice deficient for aminopeptidase N

✍ Scribed by Andreas F. Kolb, David Sorrell, Caroline Lassnig, Simon Lillico…

Book ID
120784316
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
546 KB
Volume
22
Category
Article
ISSN
0962-8819

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The nuclear transcription factor of activated T cells (NFAT) suggested to be a tumor suppressor. Here we report that two out of three NFATc3À/À and two in four NFATc3þ/À female mice developed aggressive mammary adenocarcinoma by 12.5 and 16 mo of age, respectively, with no occurrences in age-matched