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NFATc3 deficiency may contribute to the development of mammary gland adenocarcinoma in aging female mice

✍ Scribed by Hoyun Lee; Luc Chouinard; Michel Bonin; Robin N. Michel

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 131 KB
Volume: 44
Category: Article
ISSN: 0899-1987
DOI: 10.1002/mc.20136

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✦ Synopsis

The nuclear transcription factor of activated T cells (NFAT) suggested to be a tumor suppressor. Here we report that two out of three NFATc3À/À and two in four NFATc3þ/À female mice developed aggressive mammary adenocarcinoma by 12.5 and 16 mo of age, respectively, with no occurrences in age-matched wild-type littermates (N-14). Thus, our data suggest that NFATc3 can suppress the development of mammary gland tumors in female mice.

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