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Mammalian target of rapamycin (mTOR) phosphorylates inositol 1,4,5-trisphosphate receptor type 2 and increases its Ca2+ release activity

✍ Scribed by Yannik Régimbald-Dumas; Marc-Olivier Frégeau; Gaétan Guillemette


Book ID
113528462
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
994 KB
Volume
23
Category
Article
ISSN
0898-6568

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Positive regulation of inositol 1,4,5-tr
✍ Marc-Olivier Frégeau; Yannik Régimbald-Dumas; Prof. Gaétan Guillemette 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 361 KB

## Abstract The inositol 1,4,5‐trisphosphate receptor (IP~3~R), a ligand‐gated Ca^2+^ channel, is the main regulator of intracellular Ca^2+^ mobilization in non‐excitable cells. An emerging body of evidence suggests that specific regulatory control of the Ca^2+^ signaling pathway is modulated by th