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Mammalian target of rapamycin as a target in hematological malignancies

✍ Scribed by Kevin R. Kelly; Julie H. Rowe; Swaminathan Padmanabhan; Steffan T. Nawrocki; Jennifer S. Carew

Book ID
107384413
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
174 KB
Volume
6
Category
Article
ISSN
1776-2596

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## Abstract The mammalian target of rapamycin (mTOR) is a downstream effector of the phosphatidylinositol 3‐kinase (PI3K)/Akt (protein kinase B) signaling pathway, which mediates cell survival and proliferation. mTOR regulates essential signal‐transduction pathways, is involved in the coupling of g